TAK-659 hydrochloride

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TAK-659 hydrochloride

CAS No. : 1952251-28-3

Biological Activity：TAK-659 hydrochloride is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 hydrochloride induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL)[2][3][4].

Research Area：Cancer

Targets：FLT3|Syk

Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Drug Repurposing Compound Library; Anti-COVID-19 Compound Library;Orally Active Compound Library;Anti-Blood Cancer Compound Library;

Related Small Molecules:AT9283;(E/Z)-Zotiraciclib;Crotonoside;FLT3-IN-13;PDGFRα/FLT3-ITD-IN-2;FLT3/CDK4-IN-1;Lanraplenib monosuccinate;HP1142;ENMD-2076 Tartrate;ATH686;AZD2932;AKN-028 acetate;FLT3-IN-3;UNC2025 hydrochloride;Tandutinib;OXSI-2;Gilteritinib-d8;PF 477736;(R)-3-Hydroxy Midostaurin;BSc5371;SYK/JAK-IN-1;PRT062607 Hydrochloride;OTS447;MNS;PDGFRα/FLT3-ITD-IN-1;FLT3-IN-4

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