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Spadin TFA

Biological Activity：Spadin TFA, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with an IC₅₀ value of 10 nM. Spadin TFA enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis. Spadin TFA can be used for antidepressant research^[2].

Research Area：Neurological Disease

Targets：5-HT Receptor|Potassium Channel

Related Screening Libraries:Bioactive Compound Library Plus;Peptide Library;

Related Small Molecules:F 13714;Mosapride-d5;Kv3 modulator 2;Nuciferine;Renzapride;Brompheniramine-d6 maleate;Pinacidil;LY 344864 racemate;Harmine hydrochloride;AMP-PNP tetralithium;Valerenic acid;IK1 inhibitor PA-6;Arotinolol;Melitracen-d6 hydrochloride;WAY-100635;Nelotanserin;Flupentixol-d4 dihydrochloride;Cariprazine-d6 hydrochloride;Tetrahydro-β-carboline

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Structurally and synthetically diverse biologically active compounds；

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