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SKF-96365 hydrochloride
CAS No. : 130495-35-1
Biological Activity：SKF-96365 hydrochloride is a potent TRP channel blocker and a store-operated Ca2+ entry (SOCE) inhibitor. SKF-96365 hydrochloride significantly inhibits hERG, hKCNQ1/hKCNE1, hKir2.1 and hKv4.3 current, and significantly prolongs the QTc interval in isolated guinea pig hearts. SKF-96365 hydrochloride exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells[2].
Research Area：Cancer|Cardiovascular Disease
Targets：Autophagy|CRAC Channel|TRP Channel|Potassium Channel|Apoptosis
Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Membrane Transporter/Ion Channel Compound Library;Neuronal Signaling Compound Library;Anti-Cancer Compound Library;CNS-Penetrant Compound Library;Autophagy Compound Library;Anti-Cardiovascular Disease Compound Library;Anti-Alzheimer’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Mechanoreceptors Compound Library;Anti-Colorectal Cancer Compound Library ;Potassium Channel Compound Library;
Related Small Molecules:Physalin A;Bomedemstat ditosylate;V116517;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;GSK2332255B;Pregnenolone monosulfate sodium;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Kv3 modulator 2;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9
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