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SK-575-NEG
Biological Activity：SK-575-NEG (compound 28), a methylation counterpart of SK-575, is synthesized by methylation of the amino group of piperidine-2,6-dione in SK-575 as an control compound. SK-575-NEG is strongly bound to PARP1, with an IC50 of 2.64 nM. SK-575-NEG was completely ineffective in inducing PARP1 degradation in MDA-MB-436 and Capan-1 cells at concentrations up to 1 μM.
Research Area：Cancer
Targets：PARP
Related Small Molecules:Rucaparib monocamsylate;AZD-2461;Senaparib;Dehydrocorydaline;Rucaparib hydrochloride;Niraparib tosylate;G007-LK;PROTAC PARP1 degrader;UPF 1069;DP-C-4;Δ5-Avenasterol-d4;PARP14 inhibitor H10;CEP-9722;E7449;PARP1-IN-11;PI-1840;5,7-Dihydroxychromone;PARP-1/2-IN-1;(8R,9S)-Talazoparib;3-Aminobenzamide;PARP1-IN-12;PARP-1-IN-2;BRCA1-IN-1;NMS-P118;VPC-70063;G244-LM
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