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Semapimod tetrahydrochloride
CAS No. : 164301-51-3
Biological Activity：Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC50≈0.3 μM). Semapimod tetrahydrochloride inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders[2][3].
Research Area：Inflammation/Immunology
Targets：TNF Receptor|Interleukin Related|p38 MAPK
Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Clinical Compound Library;Drug Repurposing Compound Library;Differentiation Inducing Compound Library;Oxygen Sensing Compound Library;Pyroptosis Compound Library;Anti-Lung Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Neurodegenerative Disease-related Compound Library;Angiogenesis-Related Compound Library;Rare Diseases Drug Library;Antidepressant Compound Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Non-steroidal Anti-Inflammatory Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:Akt/NF-κB/JNK-IN-1;AX-024;Ginsenoside F3;Perakizumab;SB-747651A dihydrochloride;Dehydrocorydaline;PNRI-299;SKF-86002 dihydrochloride;QNZ;CTX-471;Ac-YVAD-CHO;Sinulatumolin E;Deucravacitinib;Pexmetinib;Epobis;SB 242235;Mulberroside A;Sinulatumolin D;NFAT Transcription Factor Regulator-1;TA-01;PDE4-IN-10;IL-17A antagonist 1;Kansuinine B;Ginsenoside Rc;TIC10;5(S)15(S)-DiHETE;Anti-inflammatory agent 7;IL-17A inhibitor 2;MW-150
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