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Selamectin
CAS No. : 220119-17-5
Biological Activity：Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, Lymphatic filariae, and nematode infection. Selamectin is also a potent P-glycoprotein substrate and a P-glycoprotein inhibitor with an IC50 of 120 nM[2].
Research Area：Infection
Targets：Parasite|Chloride Channel|Bacterial|P-glycoprotein
Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Anti-Infection Compound Library;Membrane Transporter/Ion Channel Compound Library;FDA-Approved Drug Library;Drug Repurposing Compound Library;Covalent Screening Library;Macrocyclic Compound Library;Antibacterial Compound Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Antiparasitic Compound library;EMA-Approved Drug Library;Cancer Stem Cells Compound Library;
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