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Safinamide mesylate

CAS No. : 202825-46-5

Biological Activity：Safinamide (FCE 26743; EMD 1195686) mesylate is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC₅₀=0.098 µM) over MAO-A (IC₅₀=580 nM). Safinamide mesylate also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC₅₀=8 µM) than at resting (IC₅₀=262 µM) potentials. Safinamide mesylate has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke et.al^[2][3].

Research Area：Neurological Disease|Cardiovascular Disease

Targets：Monoamine Oxidase

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Neuronal Signaling Compound Library;FDA-Approved Drug Library;Drug Repurposing Compound Library;Reprogramming Compound Library;Anti-Cardiovascular Disease Compound Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Neuroprotective Compound Library;Drug-Induced Liver Injury (DILI) Compound Library;Anti-Parkinson’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Mitochondria-Targeted Compound Library;Targeted Diversity Library;Rare Diseases Drug Library;Antidepressant Compound Library;EMA-Approved Drug Library;

Related Small Molecules:PXS-4728A;Hypericin;Simtuzumab;SSAO inhibitor-1;5-HT6R/MAO-B modulator 1;Glicoricone;MAO-B-IN-1;LOX-IN-3;LSD1-IN-16;β-Aminopropionitrile;Lazabemide;Monoamine oxidase/Aromatase-IN-1;PXS-5120A;Pirlindole mesylate;SSAO inhibitor-3;Ladostigil hemitartrate;MAO-B-IN-12;Pheniprazine;PF9601N

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