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Sacubitril/Valsartan
CAS No. : 936623-90-4
Biological Activity：Sacubitril/Valsartan (LCZ696), comprised Valsartan and Sacubitril (AHU377) in 1:1 molar ratio, is a first-in-class, orally bioavailable, and dual-acting angiotensin receptor-neprilysin (ARN) inhibitor for hypertension and heart failure[2][3]. Sacubitril/Valsartan ameliorates diabetic cardiomyopathy by inhibiting inflammation, oxidative stress and apoptosis[4].
Research Area：Cardiovascular Disease|Endocrinology
Targets：Angiotensin Receptor|Neprilysin|Apoptosis
Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Apoptosis Compound Library;GPCR/G Protein Compound Library;Metabolism/Protease Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;Peptidomimetic Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Anti-diabetic Compound Library;Oxygen Sensing Compound Library;Anti-Cardiovascular Disease Compound Library;Endocrinology Compound Library;Anti-COVID-19 Compound Library;Orally Active Compound Library;Neurotransmitter Receptor Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Parkinson’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Angiogenesis-Related Compound Library;Protein-protein Interaction Inhibitor Library;FDA-Approved Anticancer Drug Library;Anti-Prostate Cancer Compound Library;
Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib;Cyclovirobuxine D;STAT3-IN-10;Rigosertib sodium
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