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Ruxolitinib

CAS No. : 941678-49-5

Biological Activity：Ruxolitinib (INCB18424) is a potent and selective JAK1/2 inhibitor with IC₅₀s of 3.3 nM and 2.8 nM in cell-free assays, and has 130-fold selectivity for JAK1/2 over JAK3. Ruxolitinib induces autophagy and kills tumor cells through toxic mitophagy^[3].

Research Area：Cancer

Targets：JAK|Autophagy|Mitophagy|Apoptosis

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Apoptosis Compound Library;Epigenetics Compound Library;Immunology/Inflammation Compound Library;JAK/STAT Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Stem Cell Signaling Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;Antiviral Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Differentiation Inducing Compound Library;Reprogramming Compound Library;Anti-COVID-19 Compound Library;Orally Active Compound Library;Chemical Probe Library;FDA Approved & Pharmacopeial Drug Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Drug-Induced Liver Injury (DILI) Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Targeted Therapy Drug Library ;Anti-Obesity Compound Library;Mitochondria-Targeted Compound Library;Targeted Diversity Library;Anti-Liver Cancer Compound Library ;Rare Diseases Drug Library;Children’s Drug Library;EMA-Approved Drug Library;FDA-Approved Anticancer Drug Library;Anti-Prostate Cancer Compound Library;Non-steroidal Anti-Inflammatory Compound Library;Cancer Stem Cells Compound Library;

Related Small Molecules:Physalin A;Bomedemstat ditosylate;AZ-3;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;JAK3/BTK-IN-1;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Benzene hexabromide;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib

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