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RGB-286638 free base
CAS No. : 784210-88-4
Biological Activity：RGB-286638 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.
Research Area：Cancer
Targets：MEK|JAK|CDK|GSK-3
Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Epigenetics Compound Library;Immunology/Inflammation Compound Library;JAK/STAT Compound Library;Kinase Inhibitor Library;MAPK Compound Library;PI3K/Akt/mTOR Compound Library;Protein Tyrosine Kinase Compound Library;Stem Cell Signaling Compound Library;Wnt/Hedgehog/Notch Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Anti-Aging Compound Library;Differentiation Inducing Compound Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Ferroptosis Compound Library;Glycolysis Compound Library;Cytoskeleton Compound Library;Anti-Alzheimer’s Disease Compound Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Neurodegenerative Disease-related Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Glucose Metabolism Compound Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Antidepressant Compound Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:AZ-3;DB0614;TCS2002;Avutometinib;JAK3/BTK-IN-1;Dinaciclib;AR-A014418;AT9283;SNS-032;CC-671;Benzene hexabromide;(E/Z)-Zotiraciclib;CDK1-IN-4;CCT-251921;JAK-IN-10;BS-181;Samuraciclib hydrochloride hydrate;Baricitinib-d3;Cobimetinib racemate;JAK3-IN-6;T025;Flavopiridol;CDK8-IN-3;CDK9-IN-12;FLT3/CDK4-IN-1;GFB-12811;GSK 3 Inhibitor IX
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