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RapaLink-1
CAS No. : 1887095-82-0
Biological Activity：RapaLink-1, the third-generation bivalent mTOR inhibitor, combines Rapamycin (HY-10219) with MLN0128 (HY-13328, a second-generation mTOR kinase inhibitor) by an inert chemical linker. RapaLink-1 shows better efficacy than Rapamycin or mTOR kinase inhibitors (TORKi), potently blocking cancer-derived, activating mutants of mTOR. RapaLink-1 can cross the blood-brain barrier. RapaLink-1 binding to FKBP12 results in targeted and durable inhibition of mTORC1. RapaLink-1 plays an antithrombotic role in antiphospholipid syndrome by improving autophagy. Anticancer activity[2].
Research Area：Cancer
Targets：Autophagy|mTOR
Related Screening Libraries:Bioactive Compound Library Plus;Macrocyclic Compound Library;
Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Cyclovirobuxine D;WYE-354;L-Leucine-1-13C,15N;PI-103-d8;Palomid 529;PI-103 Hydrochloride;RMC-5552;OXA-01;L-Leucine-15N;PI3K/mTOR Inhibitor-6;PI3K/mTOR Inhibitor-1;HDACs/mTOR Inhibitor 1;Chromeceptin;hSMG-1 inhibitor 11e;PI3Kα/mTOR-IN-1;Torin 1;Dihydromyricetin;PI3K/mTOR Inhibitor-4;L-Leucine-13C6,15N;PI3K/mTOR Inhibitor-7;VS-5584;Dihydroevocarpine;Torin 2;Polyphyllin I;MHY1485
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