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Quetiapine hemifumarate

CAS No. : 111974-72-2

Biological Activity：Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pK_is of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects.

Research Area：Neurological Disease

Targets：Dopamine Receptor|5-HT Receptor

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound Library;FDA-Approved Drug Library;Drug Repurposing Compound Library;NMPA-Approved Drug Library;Orally Active Compound Library;Neurotransmitter Receptor Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Alzheimer’s Disease Compound Library;Drug-Induced Liver Injury (DILI) Compound Library;Neurodegenerative Disease-related Compound Library;Anti-Obesity Compound Library;Rare Diseases Drug Library;Antidepressant Compound Library;5-HT Receptor Compound Library;Human Metabolite Library;Coagulation and Anti-coagulation Compound Library;

Related Small Molecules:F 13714;Alizapride hydrochloride;Thioproperazine;Mosapride-d5;Bromopride-d3;Nuciferine;Glaucine;Renzapride;SB-277011 dihydrochloride;LY 344864 racemate;Harmine hydrochloride;MIF-1 TFA;Valerenic acid;Arotinolol;Sulpiride;(Rac)-Razpipadon;Melitracen-d6 hydrochloride;Clebopride malate;WAY-100635;Nelotanserin;Flupentixol-d4 dihydrochloride

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