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Pomalidomide 4′-PEG3-azide

CAS No. : 2271036-46-3

Biological Activity：Pomalidomide 4′-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4′-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1 degrader based on Rucaparib by using the PROTAC approach.

Research Area：Cancer

Targets：E3 Ligase Ligand-Linker Conjugates

Related Small Molecules:cIAP1 Ligand-Linker Conjugates 6 hydrochloride;(S,R,S)-AHPC-Me-C10-NH2;cIAP1 Ligand-Linker Conjugates 2;Glutarimide-Isoindolinone-NH-PEG3-COOH;cIAP1 Ligand-Linker Conjugates 4;(S,R,S)-AHPC-Me-C7 ester;(S,R,S)-AHPC-C2-PEG4-N3;cIAP1 Ligand-Linker Conjugates 5;cIAP1 Ligand-Linker Conjugates 7;cIAP1 Ligand-Linker Conjugates 16;(S,R,S)-AHPC-C8-NH2 hydrochloride;cIAP1 Ligand-Linker Conjugates 8;(S,R,S)-AHPC-PEG4-NH2;VHL Ligand-Linker Conjugates 15;VH032-PEG3-acetylene;(S,R,S)-AHPC-PEG2-NH2 dihydrochloride;VH032-PEG5-C6-Cl;(S,R,S)-AHPC-Me-C5-COOH

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