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PNU-159682
CAS No. : 202350-68-3
Biological Activity：PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis[2]. PNU-159682 can be used in EDV-nanocell technology to overcome drug resistance[3].
Research Area：Cancer
Targets：Topoisomerase|ADC Cytotoxin
Related Screening Libraries:Covalent Screening Library Plus;Natural Product-like Compound Library;Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Toxins for Antibody-Drug Conjugate Research Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Covalent Screening Library;Anti-Lung Cancer Compound Library;Anti-Blood Cancer Compound Library;
Related Small Molecules:Sandramycin;Gepotidacin;Topoisomerase I/II inhibitor 3;(R)-Camptothecin-d5;Dolastatin 10;Topoisomerase II inhibitor 8;FLT3-IN-13;INX-SM-56;TP3011;TAS-103 dihydrochloride;DC10SMe;Rebeccamycin;Duocarmycin TM;Fmoc-MMAE;Taltobulin;N-Me-L-Ala-maytansinol;CC-885-CH2-PEG1-NH-CH3;AZD5099;TP0480066;Topoisomerase I inhibitor 4;Camptothecin;Corydamine;SW044248;Maytansinol
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