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PLX-4720

CAS No. : 918505-84-7

Biological Activity：PLX-4720 is a potent and selective inhibitor of B-Raf^V600E with IC₅₀ of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), and 10-fold selectivity for B-Raf^V600E than wild-type B-Raf.

Research Area：Cancer

Targets：Raf

Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Anti-Cancer Compound Library;Oxygen Sensing Compound Library;Ferroptosis Compound Library;Glutamine Metabolism Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Obesity Compound Library;Targeted Diversity Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Human Metabolite Library;

Related Small Molecules:Avutometinib;AZ 628;Everafenib;L-779450;Raf inhibitor 1;RRD-251;B-Raf IN 8;TAK-632;Encorafenib;RAF mutant-IN-1;AD80;CCT241161;PLX7904;RAF-IN-1;EGFR/BRAFV600E-IN-1;MCP110;GDC-0879;B-Raf IN 1;R18;Rineterkib

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