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PD 151746

CAS No. : 181765-30-0

Biological Activity：PD151746 is a calpain inhibitor, shows a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM).
IC50 value: 0.26 ± 0.03 μM (Ki, for μ-calpain), 5.33 ± 0.77 μM (Ki, for m-calpain) [1]
Target: calpain
in vitro: The μ-calpain inhibitor PD 151746 decreases oxLDL-induced cytotoxicity. [2]

Research Area：Cardiovascular Disease

Targets：Proteasome

Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Covalent Screening Library;Anti-Cardiovascular Disease Compound Library;Ubiquitination Compound Library;Anti-Blood Cancer Compound Library;Targeted Diversity Library;

Related Small Molecules:Calpeptin;Calpain Inhibitor VI;MG-101;ONX-0914 TFA;MG-115;UK-101;SAP2-IN-1;LXE408;GSK3494245;PR-39;20S Proteasome-IN-1;M3258;PI-1840;Rpn11-IN-1;Delanzomib;Ac-ANW-AMC;Cyclotheonellazole A;Aclacinomycin A;Vimentin-IN-1;DD1;VR23;Tomatine;Gabexate mesylate;Alicapistat;Neurodegenerative Disorder-Targeting Compound 1

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