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PC945
CAS No. : 1931946-73-4
Biological Activity：PC945, a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus. PC945 is also a potent, tightly binding inhibitor of A. fumigatus sterol 14α-demethylase activity, CYP51A and CYP51B, with IC50s of 0.23 μM and 0.22 μM, respectively[2].
Research Area：Infection
Targets：Fungal|Cytochrome P450
Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Anti-Infection Compound Library;Metabolism/Protease Compound Library;Clinical Compound Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Covalent Screening Library;Antioxidant Compound Library;Oxygen Sensing Compound Library;Antifungal Compound Library;Protein-protein Interaction Inhibitor Library;
Related Small Molecules:Antifungal agent 20;SR9186;AMG-208;Debneyol;Haloprogin;Staurosporine;Ciclopirox-d11;Ciclopirox olamine;Clotrimazole-d5;(R)-Camptothecin-d5;Ticlatone;Aminothiazole;Magnesium silicate;CYP1B1-IN-1;CYP2C9/CYP2C19-IN-1;α-Terpinene;Hydroxyphenyllactic acid;Iprobenfos;Hypericin;Chlorphenesin;Moniliformin sodium salt;HLF1-11;β-Amyrin acetate;Bifonazole
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