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Paritaprevir

CAS No. : 1216941-48-8

Biological Activity：Paritaprevir (ABT-450) is a potent, orally active and antiviral non-structural protein 3/4A (NS3/4A) protease inhibitor with EC₅₀s of 1 and 0.21 nM against HCV 1a and 1b, respectively. Paritaprevir is also a SARS-CoV 3CL^pro inhibitor with an IC₅₀ of 1.31 μM. Paritaprevir is metabolized primarily by cytochrome P450 (CYP) 3A. The plasma concentration and half-life of Paritaprevir can be enhanced by Ritonavir (a CYP450 inhibitor)^[2][3][4].

Research Area：Infection

Targets：HCV|HCV Protease|SARS-CoV

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Anti-Infection Compound Library;Metabolism/Protease Compound Library;FDA-Approved Drug Library;Antiviral Compound Library;Drug Repurposing Compound Library;Macrocyclic Compound Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Hepatitis C Virus Compound Library;EMA-Approved Drug Library;

Related Small Molecules:HCV-IN-30;NS5A-IN-1;HCV-IN-38;SARS-CoV-2-IN-33;GRL-0496;Sennidin A;HCV-IN-31;Radalbuvir;Grazoprevir potassium salt;FGI-106 tetrahydrochloride;SARS-CoV-2-IN-19;Molnupiravir;SARS-CoV-2 Mpro-IN-3;BMS-986144;Oenothein B;MM3122;Ketotifen fumarate;Triton X-45(n=4);SARS-CoV-2-IN-16

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