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ONO-7475
CAS No. : 1646839-59-9
Biological Activity：ONO-7475 is a potent, selective, and orally active Axl/Mer inhibitor with IC50 values of 0.7 nM and 1.0 nM, respectively. ONO-7475 sensitizes AXL-overexpressing EGFR-mutant NSCLC cells to the EGFR-TKIs, suppresses the emergence and maintenance of tolerant cells. ONO-7475 combines with Osimertinib (HY-15772) provides a bright promise for the study of EGFR-mutated non-small cell lung cancer (NSCLC).
Research Area：Cancer
Targets：Trk Receptor|TAM Receptor
Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Kinase Inhibitor Library;Neuronal Signaling Compound Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Drug Repurposing Compound Library;Orally Active Compound Library;Anti-Lung Cancer Compound Library;
Related Small Molecules:hTrkA-IN-1;IHMT-TRK-284;Axl-IN-5;PROTAC Axl Degrader 2;ANA-12;UNC2250;Larotrectinib sulfate;N-Acetyl-5-hydroxytryptamine;R916562;LM22B-10;XL092;D5261;N-Acetyl-5-hydroxytryptamine-d3;Axl-IN-3;Gilteritinib-d8;7,8-Dihydroxyflavone;TRK-IN-18;TRK-IN-12;UNC1062;Bemcentinib;Axl-IN-6;CH7057288;Entrectinib;Pan-Trk-IN-3;RU-302;AZ-23
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