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NSC 663284
CAS No. : 383907-43-5
Biological Activity：NSC 663284 (DA-3003-1) is a potent, cell-permeable, and irreversible Cdc25 dual specificity phosphatase inhibitor, has an IC50 for Cdc25B2 of 0.21 μM. NSC 663284 exhibits mixed competitive kinetics against Cdc25A, Cdc25B(2), and Cdc25C with Ki values of 29, 95, and 89 nM, respectively. NSC 663284 inhibits NSD2 (IC50 of 170 nM) through a direct interaction with the catalytic SET domain (Kd of 370 nM)[2].
Research Area：Cancer
Targets：Histone Methyltransferase|Phosphatase
Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Epigenetics Compound Library;Metabolism/Protease Compound Library;Histone Modification Research Compound Library;Anti-Cancer Compound Library;Covalent Screening Library;Reprogramming Compound Library;Anti-Breast Cancer Compound Library;Anti-Blood Cancer Compound Library;Phosphatase Inhibitor Library;
Related Small Molecules:EEDi-5285;GNF362;EZH2-IN-2;ZLDI-8;Uralenol;BIX-01294;SGC707;(S)-HH2853;G9a-IN-1;SHP504;UNC4976;MS1943;Trimyristin;SHP099 hydrochloride;OTS186935 hydrochloride;MY10;PTP1B-IN-3 diammonium;Calyculin A;MS8815;(R)-HH2853;EPZ020411;LMPTP inhibitor 1 dihydrochloride;[pTyr5] EGFR (988-993) (TFA);Furamidine dihydrochloride;RMC-3943;EZH2-IN-12;AS1949490;PGAM1-IN-1;UNC0642
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