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Nav1.7-IN-8
CAS No. : 1432913-44-4
Biological Activity：Nav1.7-IN-8 is a potent blockage of NaV1.7 with high selectivity for the inhibition of NaV1.7 over the subtypes hNaV1.1 and hNaV1.5. Nav1.7-IN-8 inhibits CYP2C9 and CYP3A4 with an IC50 of 0.17 μM and 0.077 μM, respectively. Nav1.7-IN-8 displays significant analgesic effects in rodent models of acute and inflammatory pain.
Research Area：Inflammation/Immunology
Targets：Sodium Channel|Cytochrome P450
Related Small Molecules:SR9186;AMG-208;Lu AE98134;Zandatrigine;CYP1B1-IN-1;CYP2C9/CYP2C19-IN-1;Veratridine;Brompheniramine-d6 maleate;Hypericin;GX-674;Dibucaine;Galeterone;Sodium Channel inhibitor 2;3-Deoxyaconitine;Ranitidine;Bergapten;20(S)-Ginsenoside Rg3;Ginsenoside Rd;AS1810722;Tocainide hydrochloride;Isoglycycoumarin
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