For research use only. We do not sell to patients.

N-piperidine Ibrutinib hydrochloride

CAS No. : 2231747-18-3

Biological Activity：N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC₅₀s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively. N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC₅₀ of 7.9 nM^[2].

Research Area：Cancer

Targets：Ligands for Target Protein for PROTAC|Btk

Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Anti-Blood Cancer Compound Library;Target Protein Ligand Library;

Related Small Molecules:JAK3/BTK-IN-1;Elsubrutinib;ARQ 531;PF-06250112;PCI 29732;BI-4464;PROTAC BRD4 ligand-2;PROTAC BRD9-binding moiety 1 hydrochloride;PROTAC IRAK4 ligand-1;Apcin-A;CHMFL-EGFR-202;Avitinib;RN486;GDC-0834 Racemate;Spebrutinib besylate;Vecabrutinib;BMX-IN-1;Tolebrutinib;Ipatasertib-NH2 dihydrochloride;BTK-IN-16;(R)-Zanubrutinib;SirReal1-O-propargyl;Pirtobrutinib;CTA056;PD0325901-O-C2-dioxolane

About Us:

MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use；
Structurally and synthetically diverse biologically active compounds；
roduct quality is the key to our success and we take pride in offering only the highest-grade products.；
We provide HNMR, LC-MS, HPLC, stability testing and activity assays of our products to clients.；
Product identity, quality, purity and activity are assured by our robust quality control programs and procedures.；

Structurally and synthetically diverse biologically active compounds；

Customized order volume ranging from milligrams to kilograms scale；

We provide customer-oriented services. To explore more, please contact us at [email protected]. Our team will gladly assist you.

Top Publications Citing Use of MCE Products