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N-Desmethylclozapine
CAS No. : 6104-71-8
Biological Activity：N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic drug Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist[2].
Research Area：Infection
Targets：Drug Metabolite|Opioid Receptor|mAChR|Virus Protease
Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;Anti-Infection Compound Library;GPCR/G Protein Compound Library;Metabolism/Protease Compound Library;Neuronal Signaling Compound Library;Clinical Compound Library;Antiviral Compound Library;Neurotransmitter Receptor Compound Library;Drug Metabolite Library;Antidepressant Compound Library;Human Metabolite Library;
Related Small Molecules:VU0357017 hydrochloride;Nicotinamide N-oxide;SRPIN340;ORL1 antagonist 1;ZIKV-IN-4;TBPB;Imidafenacin;Sabcomeline;Loperamide-d6 N-Oxide;Aminothiazole;Deltorphin 2 TFA;CYP2C9/CYP2C19-IN-1;4-Hydroxyphenylbutazone;Ampyrone;MK-6884;Resveratrol-3-O-sulfate sodium;Brompheniramine-d6 maleate;Sonidegib metabolite M48;Isonicotinic acid;Cycloguanil hydrochloride;L-Lysine
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