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Multitarget AD inhibitor-1

CAS No. : 2205015-77-4

Biological Activity：Multitarget AD inhibitor-1 is a selective and reversible butyrylcholinesterase (BuChE) inhibitor with IC₅₀s of 7.22 μM and 1.55 μM for hBuChE and eqBuChE (BuChE from equine serum), respectively. Multitarget AD inhibitor-1 inhibits β-secretase (IC_50hBACE-1=41.60 μM), amyloid β aggregation (IC_50Aβ=3.09 μM), tau aggregation. Multitarget AD inhibitor-1, a diphenylpropylamine derivative, has the potential for multifunctional disease-modifying anti-Alzheimer’s research.

Research Area：Neurological Disease

Targets：Beta-secretase|Amyloid-β

Related Small Molecules:LY2886721;β-Amyloid (13-27);Saikosaponin C;β-Amyloid (1-42), (rat/mouse) (TFA);β-Amyloid (12-28) (TFA);BACE1-IN-9;BuChE-IN-5;Ginsenoside Rg1;MDR-1339;β-Amyloid (11-22);20(S)-Ginsenoside Rg3;β-Amyloid (31-35);Aβ-IN-1;Qingyangshengenin B;JNJ-40418677;HDAC6-IN-6;β-Secretase Inhibitor II;β-Amyloid (1-37) (human);CGP52411;Astrophloxine;Cassiaside;γ-Secretase modulator 12;Glabrolide;OM99-2;δ-Secretase inhibitor 11;BuChE-IN-2

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