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Mollugin
CAS No. : 55481-88-4
Biological Activity：Mollugin is an orally active and potent NF-κB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway[2][3].
Research Area：Cancer
Targets：NF-κB|Reactive Oxygen Species|VEGFR|Apoptosis|c-Myc
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