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MELK-8a
CAS No. : 1922153-17-0
Biological Activity：MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC50s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells.
Research Area：Cancer
Targets：MELK|PDGFR
Related Small Molecules:Henatinib;Flumatinib mesylate;IHMT-TRK-284;PDGFRα/FLT3-ITD-IN-2;PP58;Chiauranib;Zeteletinib;ENMD-2076 Tartrate;AZD2932;AC710 Mesylate;Tyrosine kinase-IN-1;Tandutinib;JNJ-10198409;SU4984;SU4312;Avapritinib;Masitinib;DMPQ dihydrochloride;SU14813 maleate;HG-7-85-01
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