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Losartan Carboxylic Acid
CAS No. : 124750-92-1
Biological Activity：Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[2][3][4].
Research Area：Cardiovascular Disease
Targets：Angiotensin Receptor
Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Anti-Cardiovascular Disease Compound Library;Neurotransmitter Receptor Compound Library;Angiogenesis-Related Compound Library;Human Metabolite Library;Anti-Prostate Cancer Compound Library;
Related Small Molecules:Saralasin;A81988;EMD 66684;TD-0212;Angiotensin I/II (1-6) (TFA);YS-49;TRV055;TRV056;H-Val-Pro-Pro-OH TFA;Tranilast sodium;Angiotensin amide;L162389;L-159282;CGP48369;Elisartan;Pratosartan;TRV-120027 TFA;SL910102
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