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Ki16425
CAS No. : 355025-24-0
Biological Activity：Ki16425 (Debio 0719) is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with Kis of 0.34 μM and 0.93 μM, respectively. Ki16425 (Debio 0719) reduces the LPA-induced activation of p42/p44 MAPK[2]. Ki16425 can also inhibit LPA-induced dephosphorylation of Yes-associated protein (YAP)/TAZ in HEK293A cells[3].
Research Area：Neurological Disease|Cancer
Targets：LPL Receptor
Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Immunology/Inflammation Compound Library;Anti-Cancer Compound Library;Human Metabolite Library;Anti-Pulmonary Fibrosis Compound Library;
Related Small Molecules:GSK2018682;Ozanimod hydrochloride;BMS-986020 sodium;S1p receptor agonist 2;ONO-9780307;Siponimod hemifumarate;S1P2 antagonist 1;S1P1 agonist III;Ceralifimod;H2L 5765834;S1PR1 agonist 2;RP101442;S1PR1 agonist 1;CS-2100;ASP1126;1-Oleoyl lysophosphatidic acid;Ex26;RP-001 hydrochloride;VPC 23019;CYM-5541;LPA1 receptor antagonist 1;Autotaxin-IN-6;Zectivimod;CYM5442 hydrochloride;PF-543 Citrate;LPA2 antagonist 1;LPA2 antagonist 2
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