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K-Ras ligand-Linker Conjugate 3
CAS No. : 2378261-87-9
Biological Activity：K-Ras ligand-Linker Conjugate 3 (Compound 001371) incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 3 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells.
Research Area：Cancer
Targets：Target Protein Ligand-Linker Conjugates
Related Small Molecules:K-Ras ligand-Linker Conjugate 1;BMS-1166-N-piperidine-CO-N-piperazine;MRTX849 ethoxypropanoic acid;K-Ras ligand-Linker Conjugate 6;BRD4 ligand-Linker Conjugate 1;Ahx-DM1 TFA;K-Ras ligand-Linker Conjugate 2;K-Ras ligand-Linker Conjugate 5;Desmorpholinyl Quizartinib-PEG2-COOH;K-Ras ligand-Linker Conjugate 4;(Rac)-PROTAC PARP/EGFR ligand 1;ERRα Ligand-Linker Conjugates 1;FAK ligand-Linker Conjugate 1
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
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