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JNJ-10198409
CAS No. : 627518-40-5
Biological Activity：JNJ-10198409 is a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derived growth factor receptor tyrosine kinase) inhibitor (IC50=2 nM). It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent. JNJ-10198409 has good activity against PDGFR-β kinase (IC50=4.2 nM) and PDGFR-α kinase (IC50=45 nM)[2].
Research Area：Cancer
Targets：PDGFR
Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Reprogramming Compound Library;Angiogenesis-Related Compound Library;Targeted Diversity Library;Anti-Liver Cancer Compound Library ;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Coagulation and Anti-coagulation Compound Library;
Related Small Molecules:Henatinib;Flumatinib mesylate;IHMT-TRK-284;PDGFRα/FLT3-ITD-IN-2;PP58;Chiauranib;Zeteletinib;ENMD-2076 Tartrate;AZD2932;AC710 Mesylate;Tyrosine kinase-IN-1;Tandutinib;SU4984;SU4312;Avapritinib;MELK-8a;Masitinib;DMPQ dihydrochloride;SU14813 maleate;HG-7-85-01
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