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JKC363 TFA

Biological Activity：JKC363 TFA, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC₅₀=0.5 nM) than at the MC3 receptor (44.9 nM). JKC363 TFA blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect^[2].

Research Area：Neurological Disease

Targets：Melanocortin Receptor

Related Small Molecules:Bremelanotide;MSG606 TFA;Resomelagon;Dersimelagon;Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA;Terrein;γ1-MSH TFA;SNT-207707;PF-07258669;THIQ;ACTH (11-24) (acetate);PG-931 TFA;[D-Trp8]-γ-MSH;MC-4R Agonist 1;ACTH (1-17);SNT-207858 free base;Lys-γ3-MSH(human);Nonapeptide-1;HS024 TFA;Adrenocorticotropic Hormone (ACTH) (4-10), human;SHU 9119;Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA);(p-Iodo-Phe7)-ACTH (4-10)

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