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JAK-IN-23

Biological Activity：JAK-IN-23 is an orally active double inhibitor of JAK/STAT and NF-κB. JAK-IN-23 can inhibit JAK1/2/3 with IC₅₀ values of 8.9 nM, 15 nM and 46.2 nM, respectively. JAK-IN-23 has potent inhibitory activities against interferon-stimulated genes (ISG) and NF-κB pathways with IC₅₀ values of 3.3 nM and 150.7 nM, respectively. JAK-IN-23 has great anti-inflammatory that decreases the release of various proinflammatory factors. JAK-IN-23 can be used for the research of inflammatory bowel disease (IBD).

Research Area：Inflammation/Immunology

Targets：JAK|NF-κB|STING|STAT

Related Small Molecules:AZ-3;Akt/NF-κB/JNK-IN-1;JAK3/BTK-IN-1;Icariside F2;Cirsilineol;STING agonist-3 trihydrochloride;IKKγ NBD Inhibitory Peptide TFA;Ochromycinone;AT9283;C188-9;Benzene hexabromide;Mangiferin;Antioxidant agent-5;STAT3-IN-10;(E/Z)-Zotiraciclib;ALPK1-IN-1;Regaloside A;IMD-ferulic;SN52;JAK-IN-10;C188;5-Aminosalicylic Acid-D3 hydrochloride;Baricitinib-d3;BSP16;Ginsenoside Rg1;Echinulin;JAK3-IN-6;Licochalcone D;Niclosamide monohydrate

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