IMT1

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IMT1

CAS No. : 2304621-31-4

Biological Activity:IMT1 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase (POLRMT) inhibitor. IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases.

Research Area:Cancer|Metabolic Disease

Targets:DNA/RNA Synthesis|Mitochondrial Metabolism

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