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IMT1
CAS No. : 2304621-31-4
Biological Activity：IMT1 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase (POLRMT) inhibitor. IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases.
Research Area：Cancer|Metabolic Disease
Targets：DNA/RNA Synthesis|Mitochondrial Metabolism
Related Screening Libraries:Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Metabolism/Protease Compound Library;Stem Cell Signaling Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Reprogramming Compound Library;Glutamine Metabolism Compound Library;Anti-Cancer Metabolism Compound Library;Anti-Parkinson’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Mitochondria-Targeted Compound Library;Glucose Metabolism Compound Library;Targeted Diversity Library;Cuproptosis Compound Library;Cancer Stem Cells Compound Library;
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