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I-OMe-Tyrphostin AG 538
CAS No. : 1094048-77-7
Biological Activity：I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50 of 1 µM.
Research Area：Cancer|Metabolic Disease
Targets：IGF-1R
Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Covalent Screening Library;Differentiation Inducing Compound Library;Anti-Pancreatic Cancer Compound Library;Angiogenesis-Related Compound Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;
Related Small Molecules:AZ7550 Mesylate;Picropodophyllotoxin-d6;Chromeceptin;Ganitumab;GSK1838705A;AG1024;Xentuzumab;Teprotumumab;IGF-I (24-41);IGF-I (30-41) (TFA);Robatumumab;BMS-754807;GSK1904529A;NVP-ADW742;XL228;Linsitinib-d3;BMS-536924;NVP-TAE 226;IGF-1R inhibitor-2;NVP-AEW541;NBI-31772;Figitumumab;Indirubin Derivative E804
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