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HPK1-IN-7

CAS No. : 2320462-65-3

Biological Activity：HPK1-IN-7 is a potent, orally active HPK1 (hematopoietic progenitor kinase 1, MAP4K1) inhibitor (IC₅₀=2.6 nM) with excellent family and kinome selectivity. HPK1-IN-7 shows selectivity against IRAK4 (59 nM) and GLK (140 nM). HPK1-IN-7 shows robust efficacy against MC38 syngeneic tumor model in combination with anti-PD1.

Research Area：Cancer

Targets：MAP4K

Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Anti-Cancer Compound Library;Oxygen Sensing Compound Library;Anti-Obesity Compound Library;Targeted Diversity Library;

Related Small Molecules:HPK1-IN-30;HPK1-IN-25;HPK1-IN-18;GNE-495;HPK1-IN-3;HPK1-IN-20;KY-05009;HPK1-IN-24;HPK1-IN-10;NCB-0846;HPK1-IN-11;HPK1-IN-9;SS47;HPK1-IN-26;HPK1-IN-29;HPK1-IN-14;HPK1-IN-28;HPK1-IN-19;TAK1/MAP4K2 inhibitor 1;FLT3/ITD-IN-4;HPK1-IN-17;DB1113;DMX-5804;MAP4K4-IN-3;GNE 220;RET-IN-19;HPK1-IN-27;TL4-12;HPK1-IN-12

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