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H3R antagonist 2
Biological Activity：H3R antagonist 2 (Compound 23) is a multitarget histamine H3 receptor (H3R) antagonist with a Ki of 170 nM for hH3R . H3R antagonist 2 shows inhibitory effects with IC50 values of 180, 880 and 775 nM for acetylcholinesterase, butyrylcholinesterase and human monoamine oxidase B (hMAO B), respectively. H3R antagonist 2 shows favorable anti-neuropathic pain and memory-enhancing effects. H3R can across BBB.
Research Area：Neurological Disease
Targets：Monoamine Oxidase|Histamine Receptor|Cholinesterase (ChE)
Related Small Molecules:PXS-4728A;Piperilate;Tripelennamine;BuChE-IN-5;Brompheniramine-d6 maleate;Hypericin;Samelisant;Chlorphenoxamine;AChE/BChE-IN-10;H3 receptor-MO-1;Diphenhydramine;Simtuzumab;SSAO inhibitor-1;Timosaponin AIII;ABT-239;Trimyristin;AChE-IN-10;Isoimperatorin;Pseudocoptisine chloride;Itopride-d6 hydrochloride;Ketotifen fumarate;Sinapine thiocyanate;Ranitidine;sEH/AChE-IN-1
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