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GNF4877
CAS No. : 2041073-22-5
Biological Activity：GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66 μM for mouse β (R7T1) cells).
Research Area：Metabolic Disease
Targets：GSK-3|DYRK
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Related Small Molecules:TCS2002;AR-A014418;Harmine hydrochloride;T025;GSK 3 Inhibitor IX;ID-8;Dyrk1A-IN-2;GSK-626616;GNF2133 hydrochloride;MeBIO;Cromolyn-d5 sodium;GS87;ZDWX-25;ARN25068;Haspin-IN-1;PfGSK3/PfPK6-IN-2;LDN-192960 hydrochloride;RGB-286638;Laduviglusib (GMP);GSK3 Substrate, α, β subunit;DIF-3;Bikinin;A 1070722;Indirubin-3′-monoxime;Indirubin-5-sulfonate;Aloisine RP106;CLK-IN-T3;Indirubin-3′-monoxime-5-sulphonic acid
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