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GA-017

CAS No. : 2351906-74-4

Biological Activity：GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC₅₀ values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids.

Research Area：Cancer

Targets：YAP

Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;Stem Cell Signaling Compound Library;Wnt/Hedgehog/Notch Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Transcription Factor-Targeted Library;

Related Small Molecules:YAP-TEAD-IN-1;YAP-TEAD-IN-2;TT-10;MSC-4106;VT107;AICAR;Super-TDU;Super-TDU (1-31) (TFA);TDI-011536;K-975;YAP/TAZ inhibitor-2;TED-347;TEAD-IN-3;ML-7 hydrochloride;Lats-IN-1;TEAD-IN-2;MYF-01-37;YAP/TAZ inhibitor-1;Cytochalasin D;PY-60;VT103

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