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FGTI-2734 mesylate

CAS No. : 2702297-24-1

Biological Activity：FGTI-2734 mesylate is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitor with IC₅₀s of 250 nM and 520 nM for FT and GGT, respectively. FGTI-2734 mesylate can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors.

Research Area：Cancer

Targets：Farnesyl Transferase

Related Screening Libraries:Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;

Related Small Molecules:ABT-100;CP-609754;FTI-2153 TFA;Ftase inhibitor I;FTI-277;Lonafarnib;Prenyl-IN-1;YM-53601 free base;FTI-2148 diTFA;Ftase inhibitor III;Antifungal agent 46;BMS-214662;Tipifarnib (S enantiomer);FTI 276 TFA;L-778123 hydrochloride;Arglabin;Tectol;Manumycin A;RPR107393 free base;Tubulin polymerization-IN-25;FTase-IN-1;LB42708

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