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Enpatoran
CAS No. : 2101938-42-3
Biological Activity：Enpatoran (M5049) is a potent, orally active and dual TLR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran is inactive against TLR3, TLR4 and TLR9. Enpatoran can block molecule synthetic ligands and natural endogenous RNA ligands. Enpatoran exhibits excellent pharmacokinetic properties in vivo. Enpatoran can be used for both innate and adaptive autoimmunity blocking research .
Research Area：Inflammation/Immunology
Targets：Toll-like Receptor (TLR)
Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Clinical Compound Library;Antiviral Compound Library;Small Molecule Immuno-Oncology Compound Library;Drug Repurposing Compound Library;Antioxidant Compound Library;Differentiation Inducing Compound Library;Oxygen Sensing Compound Library;Pyroptosis Compound Library;Orally Active Compound Library;
Related Small Molecules:C29;TMX-201;RS 09;ODN 20844;TLR7/8-IN-1;TLR8 agonist 5;Sulfo-ara-F-NMN;TLR7/8 antagonist 1;Gardiquimod;PF-4878691;Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH;Pepinh-TRIF TFA;Afimetoran;Schaftoside;ODN 2088;CU-CPT22;UC-1V150;Diprovocim-X;CL264;MMG-11 quarterhydrate;CU-CPT 4a;TLR7/8 agonist 4;SM-324405
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