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EHNA hydrochloride
CAS No. : 58337-38-5
Biological Activity：EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 μM) and adenosine deaminase (ADA). EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects[2].
Research Area：Cancer|Infection|Neurological Disease|Cardiovascular Disease
Targets：Phosphodiesterase (PDE)|Influenza Virus|Adenosine Deaminase
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