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Dynole 2−24
CAS No. : 1416313-72-8
Biological Activity：Dynole 2−24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2−24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM). Dynole 2−24 also shows 4.4-fold selectivity for dynamin I. Dynole 2−24 is active in-cell inhibitor of clathrin-mediated endocytosis. CME: Clathrin mediated endocytosis
Research Area：Neurological Disease
Targets：Dynamin
Related Small Molecules:Dynole 34-2;Schaftoside;Dynamin inhibitory peptide TFA;DynaMin inhibitory peptide, myristoylated;Drp1-IN-1;Mdivi-1;Hydroxy-Dynasore;Dynasore
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