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Cyclotraxin B
CAS No. : 1203586-72-4
Biological Activity：Cyclotraxin B, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B non-competitively inhibits BDNF-induced TrkB activity with an IC50 of 0.30 nM. Cyclotraxin B can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects[2][3].
Research Area：Neurological Disease
Targets：Trk Receptor
Related Screening Libraries:Bioactive Compound Library Plus;Macrocyclic Compound Library;Peptide Library;Cyclic Peptide Library;
Related Small Molecules:hTrkA-IN-1;IHMT-TRK-284;ANA-12;Larotrectinib sulfate;N-Acetyl-5-hydroxytryptamine;LM22B-10;D5261;N-Acetyl-5-hydroxytryptamine-d3;7,8-Dihydroxyflavone;TRK-IN-18;TRK-IN-12;CH7057288;Entrectinib;Pan-Trk-IN-3;ONO-7475;AZ-23;Trk-IN-6;GNF-5837;TrkA-IN-1;PF-06737007;TRK II-IN-1;Trk-IN-10;Trk-IN-9;Trk-IN-1;Sacibertinib;Pan-Trk-IN-2;TRK-IN-13
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