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CJ-2360
CAS No. : 2226742-61-4
Biological Activity：CJ-2360 is a potent and orally active ALK inhibitor with IC50s of 2.2, 4.0, 8.8, 6.3, and 8.9 nM against wild-type ALK and F1197M, G1269A, L1196M, and S1206Y ALK mutants, respectively. CJ-2360 displays potent inhibitory activity against two clinically reported ALK mutants (C1156Y and L1196M) and a few other kinases (LTK, MERTK, CLK1, DAPK1, and DAPK2) among the 468 kinases evaluated.
Research Area：Cancer
Targets：Anaplastic lymphoma kinase (ALK)
Related Small Molecules:ALK-IN-9;KRCA-0008;Alectinib-d8;MS4078;TL13-22;NVP-TAE 684;ALK5-IN-30;TL13-112;ALK-IN-22;Alectinib;ALK-IN-12;Entrectinib;ALK kinase inhibitor-1;WY-135;TL13-110;ALK inhibitor 1;Envonalkib;GSK1838705A;RIPK2-IN-1;ALK-IN-1;ALK5-IN-29;X-376;ALK-IN-21;Repotrectinib;Lorlatinib;M4K2234;MS4077
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