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cis-Lomibuvir
CAS No. : 1026785-59-0
Biological Activity：cis-Lomibuvir (cis-VX-222) is the cis-isomer of Lomibuvir. Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis.
Research Area：Infection
Targets：HCV|DNA/RNA Synthesis
Related Small Molecules:Ametantrone;HCV-IN-30;ddCTP trisodium;7-TFA-ap-7-Deaza-dA;HCV-IN-38;P1788;Thymidine-13C5,15N;NSC 617145;116-9e;Sennidin A;DNA Gyrase-IN-5;DMT-2′-F-Bz-dA;HCV-IN-31;6-Thio-2′-Deoxyguanosine;Radalbuvir;Antitumor agent-74;Grazoprevir potassium salt;Risdiplam;FGI-106 tetrahydrochloride;TH287 hydrochloride;BMS-986144;Oenothein B
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