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cis-α-(Carboxycyclopropyl)glycine
CAS No. : 117857-95-1
Biological Activity：cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC50: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na+-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes[2].
Research Area：Neurological Disease
Targets：EAAT2
Related Small Molecules:Evans Blue;Dihydrokainic acid;WAY-213613 hydrochloride;DL-TBOA ammonium;GT 949;EAAT2 activator 1;Kainic acid;LDN-212320;TFB-TBOA
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