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Bruceantinol
CAS No. : 53729-52-5
Biological Activity：Bruceantinol, a quassinoid isolated from Brucea javanica, inhibits pepper mottle virus in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC50=2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc[2].
Research Area：Cancer|Infection
Targets：STAT
Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Anti-Infection Compound Library;Immunology/Inflammation Compound Library;JAK/STAT Compound Library;Kinase Inhibitor Library;Stem Cell Signaling Compound Library;Natural Product Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Differentiation Inducing Compound Library;Medicine Food Homology Compound Library;Terpenoids Library;Traditional Chinese Medicine Active Compound Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Obesity Compound Library;Transcription Factor-Targeted Library;Anti-Colorectal Cancer Compound Library ;Anti-Cancer Natural Product Library;Antidepressant Compound Library;Anti-inflammatory Traditional Chinese Medicine Active Compound Library;Plant-Sourced Natural Product Library;Anti-Prostate Cancer Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:Cirsilineol;Ochromycinone;C188-9;STAT3-IN-10;C188;Niclosamide monohydrate;STAT3-IN-1;STAT3 degrader-1;PM-81I;Morusin;Nifuroxazide-13C6;AS1810722;α7 nAchR-JAK2-STAT3 agonist 1;HP590;Eupalinolide K;STAT3-IN-11;(R)-Reticuline-d3;JAK-IN-23;UC-514321;MM-206;SH-4-54;Scutellarin;Cucurbitacin I;ENMD-1198;SH5-07
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