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Birinapant
CAS No. : 1260251-31-7
Biological Activity：Birinapant (TL32711), a bivalent Smac mimetic, is a potent antagonist for XIAP and cIAP1 with Kds of 45 nM and less than 1 nM, respectively. Birinapant (TL32711) induces the autoubiquitylation and proteasomal degradation of cIAP1 and cIAP2 in intact cells, which results in formation of a RIPK1: caspase-8 complex, caspase-8 activation, and induction of tumor cell death. Birinapant (TL32711) targets TRAF2-associated cIAPs and abrogates TNF-induced NF-κB activation.
Research Area：Cancer
Targets：HIV|IAP|Apoptosis
Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Anti-Infection Compound Library;Apoptosis Compound Library;NF-κB Signaling Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Antiviral Compound Library;Peptidomimetic Library;Drug Repurposing Compound Library;Anti-COVID-19 Compound Library;Protein-protein Interaction Inhibitor Library;Anti-Prostate Cancer Compound Library;
Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;HIV-1 TAT (48-60);Ecteinascidin 770;MDM2-p53-IN-15;Seletracetam lithium;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;HIV-IN-2;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
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