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BACE1-IN-12

CAS No. : 2479315-19-8

Biological Activity：BACE1-IN-12 (compound 7g) is a potent and BBB-penetrated BACE1 inhibitor, with an IC₅₀ of 8.9 µM. BACE1-IN-12 shows selective BuChE (butyrylcholinesterase) inhibitory activity with an IC₅₀ of 3.2 µM. BACE1-IN-12 shows effective antioxidant effect with an IC₅₀ of 10.2 μM (DPPH). BACE1-IN-12 might be served as a potential anti-Alzheimer agent.

Research Area：Neurological Disease

Targets：Beta-secretase

Related Small Molecules:LY2886721;BACE1-IN-9;β-Secretase Inhibitor II;Cassiaside;Glabrolide;OM99-2;JNJ-67569762;β-Secretase Inhibitor III;BACE1-IN-11;Multitarget AD inhibitor-1;BACE-1 inhibitor 1;BACE1-IN-8;AM-6494;LX2343;LY2811376;COX-2-IN-22;AZD3839 free base;Aloenin;β-Secretase Inhibitor IV;AChE/BChE/BACE-1-IN-2;BACE1-IN-4;Sophoflavescenol;Aloeresin D;BACE-IN-1;BACE-1 inhibitor 2;Epiberberine chloride;BACE1-IN-2

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