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Azoramide
CAS No. : 932986-18-0
Biological Activity：Azoramide is a potent, orally active small-molecule modulator of the unfolded protein response (UPR). Azoramide improves ER protein folding and elevates ER chaperone capacity, which together protects cells against ER stress. Azoramide alleviates PLA2G6 mutant-induced ER stress through modulating unfolded protein response, and enhances the CERB signaling to rescue mitochondrial function, thereby preventing apoptosis of DA neurons. Azoramide has antidiabetic activity[2].
Research Area：Endocrinology
Targets：Reactive Oxygen Species|Bcl-2 Family|Caspase|Apoptosis|Mitochondrial Metabolism
Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;NF-κB Signaling Compound Library;Stem Cell Signaling Compound Library;Anti-Aging Compound Library;Antioxidant Compound Library;Reprogramming Compound Library;Anti-diabetic Compound Library;Oxygen Sensing Compound Library;Endocrinology Compound Library;Ferroptosis Compound Library;Endoplasmic Reticulum Stress Compound Library;Pyroptosis Compound Library;Orally Active Compound Library;Glutamine Metabolism Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Anti-Parkinson’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Mitochondria-Targeted Compound Library;Glucose Metabolism Compound Library;Cuproptosis Compound Library;Cancer Stem Cells Compound Library;
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